Thursday, August 16

Cauduceus.

I recently watched a six-part documentary series on PBS called RX For Survival. Not the snappiest name, but it was a very well-made program (narrated by Brad Pitt for those who care, not that I noticed till episode 3 - he does a great job of keeping a very even and rational tone, which is comforting in a documentary; the emotional approach has never worked for me). The first episode was about vaccines and detailed the smallpox eradication program that ended in the 70s with an entire virus wiped from the face of the planet for the first time. Of course other deadly viruses still persist, mostly in the developing world, and more are emerging all the time. The second episode went more into bacteriology and the logistical challenges faced by the World Health Organization, UNICEF, Doctors Without Borders, and other organizations who are trying to get medicines that exist to people that need them, and it's quite a challenge, nearly impossible in some places for one reason or another (warfare, lack of roads, religious mandates against medications).

I won't detail every episode, but the series as a whole touched on pretty much everything from viruses and bacteria to malnourishment and poor infrastructure, and also explored the reasons medicines lose their effectiveness, why new medicines or vaccines are often so expensive and what is involved in making them, why many drug companies have pulled out of those markets in favor of producing more lucrative pill-a-day products like Viagra and cholesterol meds, and scenarios that are being modeled and pondered by health experts around the globe concerning future epidemics or pandemics, such as the mutated form of H5N1, the avian flu virus, that everyone worries about. HIV/AIDS, polio, pallegra, scurvy, yellow fever, TB, and just about everything else you've heard of is mentioned in some detail as part of the ongoing narrative of how communicable disease and nutritional deficits were studied, understood, and cured. Some brief historical reenactments demonstrate pivotal moments of the story, from Pasteur's postulation of the germ theory of disease, doing away with all the bad airs and humours and other nonsense of the Middle Ages, to Fleming's fortuitous discovery of penicillin.

Modern human stories from Africa, Southeast Asia, South America, and even the "developed" world are focused on as well, and we get to know and see the lives of real people with names and faces who suffer from health plagues, as well as aid workers who struggle to help them. The writing is tight and balanced. It's never sentimental or sappy; you never get the feeling you're watching something made by Greenpeace or PETA. Yet it's also not strictly an armchair scientific look at disease - I found myself moved many times by the courage and selflessness of people who faced death or who felt a responsibility to risk their lives for the dying. In hospitals overcrowded and ill-equipped to handle large outbreaks, doctors and nurses worked around the clock to combat even seemingly hopelessly lost causes. Many doctors are volunteers who left lucrative Western practices to try to make an impact on public health in a larger way.

And surprisingly there have been many success stories. I wasn't left feeling gloomy about the future of world health, but rather carefully optimistic that if peace and stability can be brought to regions politically (a big if, always), local people can be empowered to take and distribute their own medications and vaccines, ensure their own sanitary water supplies, and grow and eat the right kinds of food to keep themselves healthy. And the ironic thing is, instead of this causing the population explosion you might expect, it tends to level off growth in these areas to sustainable levels, as family planning becomes part of health education and families don't feel the need to have so many children in the risk (or certainty) that most will die. All in all, I highly recommend watching this series if you get the chance. It has made me rethink my own role in the world and my (relative) comfort in the face of so much poverty and disease. But I no longer think of it as this depressing, seething wall against which individuals have no power. Nor do I see pharmaceutical companies as the root of all evil - they have a role to play like everyone else in the story, for good and for bad.

I've seen the story of a non-wealthy couple from the USA making "ambulance sidecars" for motorcycles to reach a series of African villages that otherwise would be a half-day's walk from the nearest doctor. I've seen the story of the two doctors who gave simple vitamin A drops to millions of children in Indonesia and Tibet and watched "nightblindness" disappear almost literally overnight. I've seen the story of the American-educated Botswanan doctor who returned to his native country to set up an AIDS eradication program, which is now the model upon which 70 other countries around the world are basing their own programs. There is so much that can be done to give people better lives, and not all of it is rocket science or science fiction. Some of it is just willingness or hard work. And there's hope - there doesn't have to be an endless cycle of poverty and disease, though if you watch CNN to form your world views that's the conclusion you'll undoubtedly reach as you sink further into your sofa. The problems of the world won't go away any time soon, but they will never go away if people, especially in the affluent areas of the world, don't do anything to help.

7 comments:

Sara said...

Hmm..I don't have time to comment properly on this, but will see what I can conjure up later. There are alternative views on things such as smallpox eradication...

Metamatician said...

Great, I'd love to hear them.

Sara said...

I have really mixed feelings about vaccination, and although I've modified my views over time, I still have a persistent unease that we're interfering with a process in a way that has possibly dire long term consequences for short term gain. I don't have access to my sources right now, but I've read material that offers quite convincing alternative arguments for the reasons why smallpox eradication for example, had little to do with the vaccine programme and more to do with diseases having a natural 'lifespan' in epidemiological terms, which would have meant that it was dying out before the introduction of widespread vaccination. Is this stuff propaganda? I don't know. But it seems that the pharmaceutical companies would have far more to gain in the propaganda stakes. They rule Western medicine.

Also you don't have to be a health professional to realise that the new and terrifying generation of superbugs that are now rife in many of our hospitals, are due to the overprescription of antibiotics which again were at one time thought to be the cure all for everything.

I guess like you, I don't by any means see the pharmaceutical industry as the root of all evil, but I do believe that any area where there are such vast profits to be made, needs to be examined openmindedly and not deified.

However, I've gone off into a personal mini-rant that has probably little to do with the documentaries you saw which do sound really interesting and thought provoking.

Anonymous said...

Wow, eradication of smallpox has nothing to do with pharmaceutical companies, overuse of antibiotics or any of that. The smallpox vaccine was developed aeons ago, was not under patent and was one of the cheapest life saving "medicines" ever. Try reading an account of what a devastating disease Smallpox was and you will not "wish it back".

Meta, do you have the book on Smallpox I had?

Anonymous said...

I wonder if it might take "vast profits" to develop more of the new, very EXPENSIVE, and effective drugs that are extending our lifetimes. Some of the "wonder drugs" are recreational like Viagra, but people buy them.

There may be a valid social debate whether extending our lifetimes is useful, but the drugs DO work. And most of the individuals that are alive because of them agree that they are useful.

Metamatician said...

Yes, smallpox was DEFINITELY eradicated by mankind, specifically by the World Health Organisation which had thousands or maybe tens of thousand of teams organized like an army to respond to outbreaks, whereupon they would encircle it like a firebreak by vaccinating all the people within a certain radius of the sick person. It was systematic and is well documented in many books. I have read two personally and there is no conceivable way that smallpox was on it's way down or out before that program started. It was first eliminated from West Africa, then from most of India and Bangladesh, then from East Africa and some remaining very remote areas of India. Every vaccination was catalogued and you could make an animated map if you wanted showing where the "smallpox warriors" went and how the disease disappeared behind them. So sorry, that is just way leftist propaganda and not scientific.

Vaccinations are one of the best things to have ever been developed because they prevent us from getting a disease in the first place. There are problems of course: Some ignorant and affluent hippies in places like Seattle (to cite one community highlighted in the documentary) have begun to believe this myth that the slight chance of side effects and the VERY occasional serious side effect is "not worth risking exposing their children to for a disease that doesn't occur in their part of the world anyway". It's precisely ignorance like this that will bring viral disease back into the industrialized world; we've simply forgotten how horrible things like smallpox really are and seem to regard immunizations as something akin to not eating too much fish because of the danger of mercury buildup. It's nothing of the kind: smallpox will kill you in days if you get a virulent strain, and no cure exists.

The other mistake that even doctors have been unaware of till recently is the importance of boosters for more than just MMR. Nearly all vaccines weaken significantly over time; If you have one of those craters on your arm don't feel like it means anything now because it probably doesn't. If smallpox were to reappear in the world I would sure go get a vaccination for it pronto.

As far as drug companies go, they're just companies run by boards of directors answerable to stockholders; they are not thinking organisms themselves. This is unfortunate when the market seems to steer toward designer drugs that affluent people can pay for at the expense of less profitable drugs that could save poor people's very lives, but that's not all the drug companies fault - It's OUR fault as a society for voting with our dollars. Maybe if a grass roots societal movement to forgo "stiffy" meds and put the same money into basic meds and services for Subsaharan Africa, Southeast Asia, and South and Central America, millions of lives could be saved. To blame the drugs companies for responding to market forces is just a scapegoat in my opinion. They will produce whatever they are paid to produce. And yes, they are charitable at times, at least as often as they are unscrupulous, which they certainly are in trying to get unproven drugs approved quickly, for example. Merck decided it couldn't make a profit off TB drugs anymore (I think it was TB) so it was about to scupper it's whole product line, but instead, the board members voted to give it to African nations FREE as long as they needed it, since they could continue to produce it at only a minor loss of profit which were made up for by more expensive drugs. They "did the right thing", and while much more COULD be done both by individuals and companies, not everything is a conspiracy and every Westerner an oppressor of the poor.

I don't mean this as an attack on YOU in any way, Mag, just stating the facts as I see them. I happen to have been reading a lot about epidemiology over the last year, mostly out of curiosity, and because I've toyed with the idea of being a public health worker myself to try to make my life mean something, and after awhile you begin to sift the truth from the bullshit.

Sara said...

Damn. Don't tell me I'm going to have to go back and re read all that stuff. I freely admit to the fact that I probably won't because I'm far too lazy these days and my mind is on other things. I generally back down in arguments because I don't have the mental energy for it. (Sounds of Booing!)And I know I'm capable of taking strangely alternative view points on some matters. :)

I agree about the need for boosters though. It's just a difficult issue in some situations. Nature does a much better job of bestowing life long immunity and for mild illnesses I still believe it's better to get the real thing. I've had a few instances when I was a midwife, of women beliving they were immune to rubella because they'd been vaccinated and then surprised to find that their immunity had worn off and spending weeks worrying about whether they'd come into contact with rubella which is a mild disease in small children but devastating to the unborn foetus during the first 16 weeks of pregnancy. And of course you can't vaccinate during pregnancy. Much better to have had the real thing as a small child.

I do agree about the 'stiffy' drugs Meta. What a load of old cock! (sorry)It's appalling that the West can spend so much on what are now considered cultural necessities for when as you say, the Third world is deprived of even the basics. On the obstetric front, it's considered a major catastrophe if a women dies in childbirth here in the UK. There are on average only around 8 deaths per annum here, from directly relatable causes. In parts of Africa 1 woman in 16 will die in childbirth. It leaves me cold. This simply shouldn't be.

As for life extension BD, there is always going to be a price. There are endless debates on the ethics of such things. Pity we're so keen on the preservation of life at any cost, yet euthanasia is still outlawed as something shocking and immoral.

Going to make coffee now to appease the Weirdo who's struggling with my malfunctioning car and producing Basil Fawlty- like mutterings under his breath about people who blog while there are other things to be done:)

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